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219334 β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

219334
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₂H₃₆Cl₂Cu₂N₂O₂691005-38-6

Products

Catalogue NumberPackaging Qty/Pack
219334-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
Catalogue Number219334
Brand Family Calbiochem®
SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
References
ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
Product Information
CAS number691005-38-6
FormDark brown solid
Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by Elemental Analysis
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem Certificates of Analysis

TitleLot Number
219334

References

Reference overview
Tian, W., et al. 2012. Biochemistry 51, 724.
Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-February-2017 JSW
SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
DescriptionA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
FormDark brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number691005-38-6
Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
Structure formulaStructure formula
Purity≥95% by Elemental Analysis
SolubilityDMSO (0.5 mg/ml). Poorly soluble in water.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
Toxicity Standard Handling
ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.