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194348 3ʹ-Azido-3ʹ-deoxythymidine

194348
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₀H₁₃N₅O₄30516-87-1
Description
Overview

This product has been discontinued.





Inhibitor of HIV-1 reverse transcriptase that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. Enters CNS by diffusion and causes irreversible telomere shortening.
Catalogue Number194348
Brand Family Calbiochem®
SynonymsAZT
References
ReferencesGomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.
Product Information
CAS number30516-87-1
FormWhite crystalline
Hill FormulaC₁₀H₁₃N₅O₄
Chemical formulaC₁₀H₁₃N₅O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity>99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXP2072000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

3ʹ-Azido-3ʹ-deoxythymidine SDS

Title

Safety Data Sheet (SDS) 

3ʹ-Azido-3ʹ-deoxythymidine Certificates of Analysis

TitleLot Number
194348

References

Reference overview
Gomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
SynonymsAZT
DescriptionInhibitor of HIV-1 reverse transcriptase that blocks the incorporation of nucleotides into growing DNA strands. Useful for anti-viral and anti-cancer studies. Enters CNS by diffusion. Causes irreversible telomere shortening.
FormWhite crystalline
CAS number30516-87-1
RTECSXP2072000
Chemical formulaC₁₀H₁₃N₅O₄
Structure formulaStructure formula
Purity>99% by HPLC
SolubilityH₂O (20 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
Merck USA index14, 10123
ReferencesGomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107.
Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223.
Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211.
Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53.
Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.