Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

05-23-0753 Adrenocorticotropic Hormone 1-24, Human

05-23-0753
  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Overview

This product has been discontinued.



We apologize for the inconvenience, but we do not currently have an alternative product.






Synthetic, human adrenocorticotropic hormone (amino acids 1-24). N-Terminal synthetic fragment of pituitary hormone that stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. Directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation (ED50 = 50 nM).
Catalogue Number05-23-0753
Brand Family Calbiochem®
SynonymsACTH 1-24, H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
References
ReferencesDarmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.
Product Information
CAS number16960-16-0
FormLyophilized
FormulationSold on the basis of peptide content.
Hill FormulaC₁₃₆H₂₁₀N₄₀O₃₁S
Chemical formulaC₁₃₆H₂₁₀N₄₀O₃₁S
Hygroscopic Hygroscopic
Sold on the basis of peptide contentY
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGM7915000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Adrenocorticotropic Hormone 1-24, Human Certificates of Analysis

TitleLot Number
05-23-0753

References

Reference overview
Darmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.

Citations

Title
  • Tuba Ozbay, et al. (2006) Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology 14, 1427-1437.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision18-September-2008 RFH
    SynonymsACTH 1-24, H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
    DescriptionSynthetic, human adrenocorticotropic hormone (amino acids 1-24). N-terminal synthetic fragment of the pituitary hormone, adrenocorticotropic hormone. Adrenocorticotropin from human pituitary glands consists of 39 amino acids. The first 24 amino acids are responsible for the biological activity of the hormone and are identical in all species. The remaining fragment has species-dependent differences in its amino acid sequence and is essential for the immunological specificity of ACTH, but is not necessary for activity. Directly activates G-proteins.
    FormLyophilized
    FormulationSold on the basis of peptide content.
    CAS number16960-16-0
    RTECSGM7915000
    Chemical formulaC₁₃₆H₂₁₀N₄₀O₃₁S
    Peptide SequenceH-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
    Purity≥98% by HPLC
    Solubility5% Acetic Acid (1 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    Merck USA index14, 134
    ReferencesDarmon, P., et al. 1999. Eur. J. Endocrinol. 140, 51.
    Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
    Mertz, L.M., and Catt, K.J. 1991. Proc. Natl. Acad. Sci. USA 88, 8525.
    Sieber, P., et al. 1972. Helv. Chim. Acta 55, 1243.
    Lee, T., et al. 1961. J. Biol. Chem. 236, 2970.
    Citation
  • Tuba Ozbay, et al. (2006) Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. Endocrinology 14, 1427-1437.