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124005 Akt Inhibitor - Calbiochem

124005
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₅₈O₁₀

Products

Catalogue NumberPackaging Qty/Pack
124005-1MG Plastic ampoule 1 mg
Description
OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
Catalogue Number124005
Brand Family Calbiochem®
Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
References
ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.
Product Information
ATP CompetitiveY
FormWhite to off-white solid
Hill FormulaC₃₀H₅₈O₁₀
Chemical formulaC₃₀H₅₈O₁₀
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationThis Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>5.0 µM for Akt (PKB)
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Akt Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
124005

References

Reference overview
Hu, Y., et al. 2000 J. Med. Chem. 43, 3045.

Brochure

Title
Akt
Biologics 31.1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-June-2011 JSW
Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₅₈O₁₀
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (200 mg/ml). Use anhydrous DMSO for reconstitution.
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Toxicity Standard Handling
ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.