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208710 [Ala²⁸⁶]-Ca2+/Calmodulin Kinase II Inhibitor 281-301

208710
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₀₈H₁₈₇N₃₉O₂₇S₂
Description
Overview

This product has been discontinued.





A synthetic peptide corresponding to residues 281-301 of the CaM kinase II α-subunit. Acts as a potent inhibitor of CaM kinase II catalytic fragment (IC50 = 2 µM). The inhibition is competitive with respect to ATP and noncompetitive with respect to peptide substrate.
Catalogue Number208710
Brand Family Calbiochem®
SynonymsCaM Kinase II Inhibitor 281-301, MHRQEAVDCLKKFNARRKLKG-NH₂
References
ReferencesSmith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.
Product Information
ATP CompetitiveY
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
Chemical formulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
Sold on the basis of peptide contentY
Applications
Biological Information
Primary Targetcam Kinase-2
Primary Target IC<sub>50</sub>2 µM
Purity≥95% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

[Ala²⁸⁶]-Ca2+/Calmodulin Kinase II Inhibitor 281-301 Certificates of Analysis

TitleLot Number
208710

References

Reference overview
Smith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
SynonymsCaM Kinase II Inhibitor 281-301, MHRQEAVDCLKKFNARRKLKG-NH₂
DescriptionA synthetic peptide corresponding to residues 281-301 of the α subunit of CaM kinase II. Acts as a potent inhibitor (IC50 = 2 µM) of CaM kinase II catalytic fragment. Acts in a competitive manner with respect to ATP and in a noncompetitive manner with respect to peptide substrate. It contains the autoinhibitory domain of CaM kinase II, as well as the initial autophosphorylation site (Thr286).
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₁₀₈H₁₈₇N₃₉O₂₇S₂
Peptide SequenceH-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-NH₂
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSmith, M.K., et al. 1992. J. Biol. Chem. 267, 1761.
Colbran, R.J., et al. 1988. J. Biol. Chem. 264, 4800.