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126871 Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem

126871
  
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₄N₄O₃852529-97-0
Description
OverviewA cell-permeable and reversible Alsterpaullone (Cat. No. 126870) derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 µM). Displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). Shown to inhibit other kinases in a commercially available testing screen panel (pIC50 = −logIC50[M]; pIC50 = ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 µM).
Catalogue Number126871
Brand Family Calbiochem®
Synonyms3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile
References
ReferencesKunick, C., et al. 2005. ChemBioChem. 6, 541.
Product Information
CAS number852529-97-0
ATP CompetitiveY
FormLight orange solid
Hill FormulaC₁₉H₁₄N₄O₃
Chemical formulaC₁₉H₁₄N₄O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdkl/Gsk-3β, Cyclin B
Primary Target IC<sub>50</sub>230 pM and 800 pM, [ATP] = 15 µM, against Cdk1/cyclin B and GSK-3β, respectively
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem Certificates of Analysis

TitleLot Number
126871

References

Reference overview
Kunick, C., et al. 2005. ChemBioChem. 6, 541.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
Synonyms3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile
DescriptionA cell-permeable and reversible Alsterpaullone (Cat. No. 126870) derivative that acts as a highly potent and ATP-competitiveinhibitor of Cdk/GSK-3 family serine/threonine kinases (IC50 = 230 pM and 800 pM for cdk1/cyclin B and Gsk-3β, respectively; [ATP] = 15 µM). Displays ~130-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). Shown to inhibit tyrosine kinases only at higher concentrations (pIC50 = −logIC50[M]; pIC50 ~7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 µM).
FormLight orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number852529-97-0
Chemical formulaC₁₉H₁₄N₄O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (10 mg/ml). Slight warming may be required for complete solubilization.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKunick, C., et al. 2005. ChemBioChem. 6, 541.