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219387 Anti-Cathepsin L Rabbit pAb

219387
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes the latent and active forms of cathepsin L.
Catalogue Number219387
Brand Family Calbiochem®
References
ReferencesChauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
Kane, S.E., and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1, 137.
Barrett, A., et al. 1981. Meth.Enzymol. 80, 535.
Product Information
FormLiquid
FormulationUndiluted serum.
Preservative≤0.1% sodium azide
Applications
Key Applications Immunoblotting (Western Blotting)
Application NotesImmunoblotting (1:1000, colorimetric)
Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogenrecombinant, human cathepsin L fusion protein expressed in E. coli
ImmunogenHuman
HostRabbit
IsotypeIgG
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Anti-Cathepsin L Rabbit pAb Certificates of Analysis

TitleLot Number
219387

References

Reference overview
Chauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
Kane, S.E., and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1, 137.
Barrett, A., et al. 1981. Meth.Enzymol. 80, 535.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2007 RFH
ApplicationImmunoblotting (1:1000, colorimetric)
DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~39 kDa latent and the ~21 kDa and ~5 kDa active forms of cathepsin L.
BackgroundCathepsin L is a cysteine proteinase expressed in a variety of cells. The latent ~39 kDa pro-cathepsin L must be processed to the active two-chain form made up of ~21 and ~5 kDa subunits. The pro peptide contains 96 amino acids. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. High levels of cathepsin L expression has been demonstrated for many human tumors including cancers of the kidney, lung, colon, breast and ovary.
HostRabbit
Immunogen speciesHuman
Immunogenrecombinant, human cathepsin L fusion protein expressed in E. coli
IsotypeIgG
Specieshuman
FormLiquid
FormulationUndiluted serum.
Preservative≤0.1% sodium azide
CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Storage -20°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesChauhan, S.S., et al. 1991. Cancer Res. 51, 1487.
Kane, S.E., and Gottesman, M.M. 1990. In Seminars in Cancer Biology, ed, M.M. Gottesman, Vol 1, 137.
Barrett, A., et al. 1981. Meth.Enzymol. 80, 535.