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178492 Apoptosis Activator II

178492
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₉Cl₂NO₂79183-19-0
Description
Overview

This product has been discontinued.





A cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 µM for Jurkat, Molt-4, and CCRF-CEM) and shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1.
Catalogue Number178492
Brand Family Calbiochem®
Synonyms1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione
References
ReferencesNguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
Product Information
CAS number79183-19-0
FormOrange solid
Hill FormulaC₁₅H₉Cl₂NO₂
Chemical formulaC₁₅H₉Cl₂NO₂
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Apoptosis Activator II Certificates of Analysis

TitleLot Number
178492

References

Reference overview
Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonyms1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione
DescriptionA cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner. Shown to induce apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Cytotoxicity is reported to be selective for tumor cells (IC50 <10 µM for Jurkat, Molt-4, and CCRF-CEM cells). Exhibits little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number79183-19-0
Chemical formulaC₁₅H₉Cl₂NO₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533.