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189484 Autocamtide-2 Related Inhibitory Peptide II - Calbiochem

189484
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₇₁H₁₂₃N₂₃O₁₉
Description
Overview

This product has been discontinued.



An AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM).

Catalogue Number189484
Brand Family Calbiochem®
SynonymsKKKLRRQEAFDAL, A3K/V10F-AIP, AIP-II
References
ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₁H₁₂₃N₂₃O₁₉
Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCAM Kinase-2
Primary Target IC<sub>50</sub>4.1 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Autocamtide-2 Related Inhibitory Peptide II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Autocamtide-2 Related Inhibitory Peptide II - Calbiochem Certificates of Analysis

TitleLot Number
189484

References

Reference overview
Ishida, A., et al. 1998. FEBS Lett. 427, 115.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
SynonymsKKKLRRQEAFDAL, A3K/V10F-AIP, AIP-II
DescriptionAn autocamtide-2 related inhibitory peptide (AIP) analog in which Ala3 and Val10 have been replaced with Lys and Phe, respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII) (IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP (Cat. No. 189480). Inhibits PKC at higher concentrations (IC50 = 1 µM), but does not affect the activities of CaMKIV or PKA (IC50 >100 µM).
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₇₁H₁₂₃N₂₃O₁₉
Peptide SequenceH-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesIshida, A., et al. 1998. FEBS Lett. 427, 115.