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203704 BPIQ-II

203704
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀BrN₅171179-32-1
Description
Overview

This product has been discontinued.





A cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). Blocks EGF-mediated mitogenesis in Swiss/3T3 cells (IC50 = 46 nM).
Catalogue Number203704
Brand Family Calbiochem®
Synonyms8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline
References
ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
Product Information
CAS number171179-32-1
FormPale pink solid
Hill FormulaC₁₅H₁₀BrN₅
Chemical formulaC₁₅H₁₀BrN₅
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>8 pM
Secondary targetgrowth factor mediated mitogenisis in swiss 3T3 cells (Ki = 46 nM)
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

BPIQ-II Certificates of Analysis

TitleLot Number
203704

References

Reference overview
Rewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline
DescriptionA cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.008 nM). Blocks growth factor mediated mitogenesis in Swiss 3T3 cells (IC50 = 46 nM).
FormPale pink solid
Intert gas (Yes/No) Packaged under inert gas
CAS number171179-32-1
Chemical formulaC₁₅H₁₀BrN₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRewcastle, G.W., et al. 1996. J. Med. Chem. 39, 918.