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203294 Bisindolylmaleimide III, Hydrochloride

203294
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₃H₂₀N₄O₂ · HCl683775-59-9
Description
Overview

This product has been discontinued.



Please refer to our complete listing of bisindolylmaleimide compounds and other protein kinase C inhibitors for possible alternatives.






A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 26 nM). May inhibit protein kinase A at much higher concentrations (IC50 = 500 nM).
Catalogue Number203294
Brand Family Calbiochem®
Synonyms2-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
References
ReferencesFabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Product Information
CAS number683775-59-9
FormRed solid
Hill FormulaC₂₃H₂₀N₄O₂ · HCl
Chemical formulaC₂₃H₂₀N₄O₂ · HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>26 nM
Secondary targetPKA (IC₅₀ = 500 nM)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Bisindolylmaleimide III, Hydrochloride SDS

Title

Safety Data Sheet (SDS) 

Bisindolylmaleimide III, Hydrochloride Certificates of Analysis

TitleLot Number
203294

References

Reference overview
Fabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
DescriptionA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 26 nM). It also inhibits protein kinase A at much higher concentrations (IC50 = 500 nM).
FormRed solid
CAS number683775-59-9
Chemical formulaC₂₃H₂₀N₄O₂ · HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or H₂O (1 mg/ml). Slight warming may be required for complete solubilization in water.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesFabre, S., and Prudhomme, M. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.