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203675 Bombesin, Free Base

203675
  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of IP3 channel modulators for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A tetradecapeptide that activates a cascade of biochemical reactions including Ins(1,4,5)P3-induced mobilization of intracellular Ca2+, protein kinase C activation, Na+,and K+ fluxes, and cAMP production. Potent mitogen of Swiss/3T3 cells. Stimulates phospholipase D in Swiss/3T3 fibroblasts.
Catalogue Number203675
Brand Family Calbiochem®
SynonymsH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂
References
ReferencesOlivier, A.R., et al. 1996. Biochem. J. 318, 519.
Wang, J.L., et al. 1996. Biochem. J. 320, 87.
Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
Panula, P. 1986. Med. Biol. 64, 177.
Product Information
CAS number31362-50-2
FormWhite to off-white lyophilized solid
Hill FormulaC₇₁H₁₁₀N₂₄O₁₈S
Chemical formulaC₇₁H₁₁₀N₂₄O₁₈S
Hygroscopic Hygroscopic
Sold on the basis of peptide contentY
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (Pyr = 5-oxoPro)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBD3480000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Bombesin, Free Base Certificates of Analysis

TitleLot Number
203675

References

Reference overview
Olivier, A.R., et al. 1996. Biochem. J. 318, 519.
Wang, J.L., et al. 1996. Biochem. J. 320, 87.
Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
Panula, P. 1986. Med. Biol. 64, 177.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
SynonymsH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂
DescriptionA tetradecapeptide that activates a cascade of biochemical reactions including Ins(1,4,5)P3-induced mobilization of intracellular Ca2+, Na+ and K+ fluxes, protein kinase C activation, and cAMP production. Acts as a mitogen and growth factor for cells in culture. The bombesin receptor in Swiss 3T3 cells is a G-protein linked neuropeptide receptor. Stimulates phospholipase D and phospholipase A2 activity in Swiss 3T3 fibroblasts. Increases the release of acetylcholine from myenteric plexus neurons via a PKC-dependent mechanism. Stimulates pancreatic growth, hypothermia, hypoglycemia, and satiety in mammals. Stimulates hormone secretion by the gastrointestinal tract, including gastrin, cholecystokinin, insulin, glucagon, prolactin, and growth hormone.
FormWhite to off-white lyophilized solid
CAS number31362-50-2
RTECSBD3480000
Chemical formulaC₇₁H₁₁₀N₂₄O₁₈S
Peptide SequenceH-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (Pyr = 5-oxoPro)
Purity≥97% by HPLC
Solubility5% Acetic acid (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 1329
ReferencesOlivier, A.R., et al. 1996. Biochem. J. 318, 519.
Wang, J.L., et al. 1996. Biochem. J. 320, 87.
Briscoe, C.P., et al. 1995. Biochem. J. 306, 115.
Mulholland, M.W., and Simeone, D.M. 1993. J. Surg. Res. 54, 389.
Agostinis, P., et al. 1992. J. Biol. Chem. 267, 9732.
Currie, S., et al. 1992. J. Biol. Chem. 267, 6056.
Alexander, R.W., et al. 1988. Cancer Res. 48, 1439.
Panula, P. 1986. Med. Biol. 64, 177.