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219676 CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem

219676
  
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₇Cl₂N₃O₂S774549-97-2
Description
OverviewA cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
Catalogue Number219676
Brand Family Calbiochem®
Synonyms7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
References
ReferencesRobert, R., et al. 2008. Mol. Pharmacol. 73, 478.
Product Information
CAS number774549-97-2
FormWhite solid
Hill FormulaC₁₉H₁₇Cl₂N₃O₂S
Chemical formulaC₁₉H₁₇Cl₂N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem Certificates of Analysis

TitleLot Number
219676

References

Reference overview
Robert, R., et al. 2008. Mol. Pharmacol. 73, 478.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
DescriptionA cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 & 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number774549-97-2
Chemical formulaC₁₉H₁₇Cl₂N₃O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRobert, R., et al. 2008. Mol. Pharmacol. 73, 478.