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208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

208743
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₆H₄₀N₄O₆145731-49-3

Products

Catalogue NumberPackaging Qty/Pack
208743-1MG Plastic ampoule 1 mg
208743-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
Catalogue Number208743
Brand Family Calbiochem®
SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
References
ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
James, T., et al. 1998. J. Neurosci. Res. 51, 218.
Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Bartus, R.T., et al. 1994. Stroke 25, 2265.
Product Information
CAS number145731-49-3
ATP CompetitiveN
FormWhite to off-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₆H₄₀N₄O₆
Chemical formulaC₂₆H₄₀N₄O₆
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem Certificates of Analysis

TitleLot Number
208743

References

Reference overview
Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
James, T., et al. 1998. J. Neurosci. Res. 51, 218.
Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Bartus, R.T., et al. 1994. Stroke 25, 2265.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 JSW
SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
DescriptionA cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, active site inhibitor of calpain-1 (Ki = 140 nM) and calpain-2 (Ki = 41 nM). Weakly inhibits cathepsin B (Ki = 6.9 µM). Shown to inhibit calpain-m-mediated degradation of neurofilament protein (NFP) (IC50 = 600 nM). Also shown to exhibit neuroprotective effects in the central nervous system following focal ischemia. Reported to protect against reovirus-induced myocarditis in mice.
FormWhite to off-white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number145731-49-3
Chemical formulaC₂₆H₄₀N₄O₆
Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
James, T., et al. 1998. J. Neurosci. Res. 51, 218.
Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Bartus, R.T., et al. 1994. Stroke 25, 2265.