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218200 Cardiotrophin-1, Human, Recombinant, E. coli

218200
  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Overview

This product has been discontinued.





Recombinant, human cardiotrophin-1 expressed in E. coli. A cytokine with structural similarities to interleukin-6. Promotes the survival of neonatal cardiomyocytes via the activation of an anti-apoptotic signaling pathway requiring MAP kinases. Induces a distinct hypertrophic response to endothelin-1 in cultured neonatal cardiomyocytes. Also induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.
Catalogue Number218200
Brand Family Calbiochem®
SynonymsrhCT-1
References
ReferencesChandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.
Product Information
FormLyophilized
Applications
Biological Information
Biological activityED₅₀: ≤1 ng/ml as measured by the ability of CT-1 to induce proliferation of TF-1 cells in a dose-dependent manner
Purity≥99% by HPLC; ≥99% by SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cardiotrophin-1, Human, Recombinant, E. coli Certificates of Analysis

TitleLot Number
218200

References

Reference overview
Chandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-June-2008 RFH
SynonymsrhCT-1
DescriptionRecombinant, human cardiotrophin-1 expressed in E. coli. A cytokine with structural similarities to interleukin-6. Promotes the survival of neonatal cardiomyocytes via the activation of an anti-apoptotic signaling pathway requiring MAP kinases. Induces a distinct hypertrophic response to endothelin-1 in cultured neonatal cardiomyocytes. Also induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.
FormLyophilized
Purity≥99% by HPLC; ≥99% by SDS-PAGE
Biological activityED₅₀: ≤1 ng/ml as measured by the ability of CT-1 to induce proliferation of TF-1 cells in a dose-dependent manner
SolubilityReconstitute in 100 µl H₂O. For more diluted concentrations, add a stabilizing protein such as BSA (100 µg/ml).
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.