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218716 Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem

218716
  
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₂₀FN₅ • 2HCl950912-80-8
Description
Overview

This product has been discontinued.



A cell-permeable tri-substituted imidazole compound that acts as a potent and reversible inhibitor of casein kinase Iε/δ (IC50 = 7.7 and 14 nM, respectively) with modest to excellent selectivity over EGFR and p38 MAPK (IC50 = 150 and 190 nM, respectively) and over 43 related kinases (IC50 > 0.3 to 30 µM), and a panel containing 116-receptors, transporters and other enzymes. Shown to inhibit PER3 nuclear translocation in GFP-PER3 and CKIε-cotransfected COS7 cells (EC50 = 290 nM), and induce phase delays in circadian rhythms of monkeys & rats model (10 - 100 mg, s.c.); further, attenuate the locomotor stimulant response to methamphetamine.

Catalogue Number218716
Brand Family Calbiochem®
Synonyms4-(3-Cyclohexyl-5-(4-fluorophenyl)-3H-imidazol-4-yl)-pyrimidin-2-ylamine, 2HCl
References
ReferencesBryant, C.D., et al. 2009. Psychopharmacology 203, 703.
Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.
Product Information
CAS number950912-80-8
FormOff-white solid
Hill FormulaC₁₉H₂₀FN₅ • 2HCl
Chemical formulaC₁₉H₂₀FN₅ • 2HCl
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsSoluble in DMSO (< 100 mM) or H2O ( < 100 mM); aliquot & store at -20*C; stable for 6 months. Most likely to compete with ATP.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem Certificates of Analysis

TitleLot Number
218716

References

Reference overview
Bryant, C.D., et al. 2009. Psychopharmacology 203, 703.
Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.