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219479 Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem

219479
  
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₃H₁₅NO₂S300801-52-9
Description
OverviewA cell-permeable dihydrobenzothiazolo compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of Clk-family of kinases (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 µM for mClk4, mClk1, mClk2, and mClk3, respectively). Does not affect the activities of SRPK1, SRPK2, PKA, or PKC up to 1 µM. Shown to alter the regulation of alternative splicing mediated by phosphorylation of Ser/Arg-rich (SR) proteins both in vitro and in vivo. Suppresses early Xenopus developmental abnormality induced by excess levels of Clk-activity.
Catalogue Number219479
Brand Family Calbiochem®
Synonyms(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003
References
ReferencesMuraki, M., et al. 2004. J. Biol. Chem. 279, 24246.
Product Information
CAS number300801-52-9
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₃H₁₅NO₂S
Chemical formulaC₁₃H₁₅NO₂S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetmClk4, mClk1, mClk2, mClk3
Primary Target IC<sub>50</sub>15 nM, 20 nM, 200 nM, >10 µM for mClk4, mClk1, mClk2, and mClk3, respectively
Primary Target K<sub>i</sub>10 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdc2-Like Kinase Inhibitor, TG003 - CAS 300801-52-9 - Calbiochem Certificates of Analysis

TitleLot Number
219479

References

Reference overview
Muraki, M., et al. 2004. J. Biol. Chem. 279, 24246.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 JSW
Synonyms(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003
DescriptionA cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of the Clk family of kinases (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM for mClk4, 20 nM for mClk1, and 200 nM for mClk2). However, it inhibits mClk3 only at higher concentrations (IC50 > 10 µM). Does not affect the activities of SRPK1, SRPK2, PKA, or PKC at concentrations up to 1 µM. Shown to alter the regulation of alternative splicing that is mediated by phosphorylation of Ser/Arg-rich (SR) proteins both in vitro and in vivo. Suppresses early Xenopus developmental abnormalities induced by excess levels of Clk activity.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number300801-52-9
Chemical formulaC₁₃H₁₅NO₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml) or Methanol (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMuraki, M., et al. 2004. J. Biol. Chem. 279, 24246.