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204863 Complement iC3b, Human

204863
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
204863-250UG Plastic ampoule 250 μg
Description
OverviewNative, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
Catalogue Number204863
Brand Family Calbiochem®
References
ReferencesRosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.
Product Information
FormLiquid
FormulationIn PBS, pH 7.2.
PreservativeNone
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by SDS-PAGE
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsIgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Complement iC3b, Human SDS

Title

Safety Data Sheet (SDS) 

Complement iC3b, Human Certificates of Analysis

TitleLot Number
204863

References

Reference overview
Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
DescriptionNative, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α' polypeptides of M.W. 43,000 and M.W. 63,000 are disulfide bonded to the intact C3 b-chain (M.W. 75,000). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
FormLiquid
FormulationIn PBS, pH 7.2.
Concentration Label Please refer to vial label for lot-specific concentration
SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥90% by SDS-PAGE
ContaminantsIgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
PreservativeNone
Storage ≤ -70°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesRosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol. 153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol. 37, 217.