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208292 L-Type Calcium Channel Blocker

208292
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₁₉ClN₂O₂S387350-81-4
Description
Overview

This product has been discontinued.





A cell-permeable sulfonamide compound that reversibly interacts with the benzothiazepine-binding site and acts as a cardiac tissue selective L-type voltage gated Ca2+-channel activity inhibitor. Shown to display negative chronotropic activity with minimal vasorelaxation.
Catalogue Number208292
Brand Family Calbiochem®
Synonyms(N-Cyclopropyl-N-piperidin-4-yl)-4-chlorobenzenesulfonamide
References
ReferencesCarosati, E., et al. 2006. J. Med. Chem. 49, 5206.
Product Information
CAS number387350-81-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₉ClN₂O₂S
Chemical formulaC₁₄H₁₉ClN₂O₂S
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCardiac tissue selective L-type voltage gated Ca2+-channel activity inhibitor
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

L-Type Calcium Channel Blocker Certificates of Analysis

TitleLot Number
208292

References

Reference overview
Carosati, E., et al. 2006. J. Med. Chem. 49, 5206.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms(N-Cyclopropyl-N-piperidin-4-yl)-4-chlorobenzenesulfonamide
DescriptionA cell-permeable sulfonamide compound that reversibly interacts with the benzothiazepine-binding site and acts as a cardiac tissue selective L-type voltage gated Ca2+-channel activity inhibitor. Shown to display negative chronotropic activity with minimal vasorelaxation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number387350-81-4
Chemical formulaC₁₄H₁₉ClN₂O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesCarosati, E., et al. 2006. J. Med. Chem. 49, 5206.