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531206 Mnk2 Inhibitor IV - Calbiochem

531206
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₈N₄O₃S
Description
Overview

This product has been discontinued.



A cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM. Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531206
Brand Family Calbiochem®
SynonymsMitogen-activated protein kinase-interacting kinase 2
References
ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.
Product Information
FormYellow powder
Hill FormulaC₁₇H₁₈N₄O₃S
Chemical formulaC₁₇H₁₈N₄O₃S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMnk2
Primary Target K<sub>i</sub>370 nM
Purity>98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531206 0

Documentation

Mnk2 Inhibitor IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Diab, S., et al. 2014. ChemMedChem. 9, 962.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-December-2014 JSW
SynonymsMitogen-activated protein kinase-interacting kinase 2
DescriptionA cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM in MV4-11 cells). Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₈N₄O₃S
Purity>98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.