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05-23-3802 Sarafotoxin S6b, Atractaspsis engaddensis

05-23-3802
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₁₀H₁₅₉N₂₇O₃₄S₅116303-65-2
Description
Overview

This product has been discontinued.

Please refer to our complete listing of endothelin receptor agonists for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.






Endothelin-related peptide that binds to the endothelin receptor in various tissues (Kd = 150 pM). Increases intracellular Ca2+ levels by activating ETA receptors. Exhibits vasoconstrictor activity and stimulates protein synthesis.
Catalogue Number05-23-3802
Brand Family Calbiochem®
SynonymsSRTX-b, CSCKDMTDKECLYFCHQDVIW
References
ReferencesBacon, C.R., and Davenport, A.P. 1996. Br. J. Pharmacol. 117, 986.
Bax, W.A., et al. 1994. Br. J. Pharmacol. 113, 1471.
Koyama, Y., et al. 1993. Brain Res. 600, 81.
Sugden, P.H., et al. 1993. Biochim. Biophys. Acta 1175, 327.
Watanabe, C., et al. 1993. Br. J. Pharmacol. 108, 30.
Marsault, R., et al. 1991. Am. J. Physiol. 261, C987.
Product Information
CAS number116303-65-2
FormLyophilized
FormulationSold on the basis of peptide content.
Hill FormulaC₁₁₀H₁₅₉N₂₇O₃₄S₅
Chemical formulaC₁₁₀H₁₅₉N₂₇O₃₄S₅
Sold on the basis of peptide contentY
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Cys¹-Ser-Cys³-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys¹¹-Leu-Tyr-Phe-Cys¹⁵-His-Gln-Asp-Val-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Sarafotoxin S6b, Atractaspsis engaddensis Certificates of Analysis

TitleLot Number
05-23-3802

References

Reference overview
Bacon, C.R., and Davenport, A.P. 1996. Br. J. Pharmacol. 117, 986.
Bax, W.A., et al. 1994. Br. J. Pharmacol. 113, 1471.
Koyama, Y., et al. 1993. Brain Res. 600, 81.
Sugden, P.H., et al. 1993. Biochim. Biophys. Acta 1175, 327.
Watanabe, C., et al. 1993. Br. J. Pharmacol. 108, 30.
Marsault, R., et al. 1991. Am. J. Physiol. 261, C987.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-September-2008 RFH
SynonymsSRTX-b, CSCKDMTDKECLYFCHQDVIW
DescriptionEndothelin-related peptide that binds to the endothelin receptor in various tissues (Kd = 150 pM). Increases intracellular Ca2+ levels by activating ETA receptors. Has vasoconstrictor activity and stimulates protein synthesis.
FormLyophilized
FormulationSold on the basis of peptide content.
CAS number116303-65-2
Chemical formulaC₁₁₀H₁₅₉N₂₇O₃₄S₅
Peptide SequenceH-Cys¹-Ser-Cys³-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys¹¹-Leu-Tyr-Phe-Cys¹⁵-His-Gln-Asp-Val-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Purity≥97% by HPLC
Solubility5% Acetic acid (1 mg/ml)
Storage -20°C
Protect from moisture
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Harmful
ReferencesBacon, C.R., and Davenport, A.P. 1996. Br. J. Pharmacol. 117, 986.
Bax, W.A., et al. 1994. Br. J. Pharmacol. 113, 1471.
Koyama, Y., et al. 1993. Brain Res. 600, 81.
Sugden, P.H., et al. 1993. Biochim. Biophys. Acta 1175, 327.
Watanabe, C., et al. 1993. Br. J. Pharmacol. 108, 30.
Marsault, R., et al. 1991. Am. J. Physiol. 261, C987.