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  • Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

Nature genetics (2001-06-30)
Z Ma, S W Morris, V Valentine, M Li, J A Herbrick, X Cui, D Bouman, Y Li, P K Mehta, D Nizetic, Y Kaneko, G C Chan, L C Chan, J Squire, S W Scherer, J K Hitzler
PMID11431691
ABSTRACT

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.