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574662

Survivin Inhibitor, YM155

Name: Survivin Inhibitor, YM155
Brand: MM

The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.

Synonym(s):

Survivin Inhibitor, YM155, Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₉BrN₄O₃

CAS Number:

781661-94-7

Molecular Weight:

443.29

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

≥95% (HPLC)

form

solid

potency

540 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Cc1n(CC2=NC=CN=C2)C(C3=O)=C([n+]1CCOC)C(C4=C3C=CC=C4)=O.[Br-]

InChI

1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1

InChI key

QBIYUDDJPRGKNJ-UHFFFAOYSA-M

Description

General description

A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC₅₀ = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Interleukin enhancer-binding factor 3 (ILF3/NF110)

Reversible: yes

Secondary Target
Unknown

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Nakamura, N., et al. 2012. Mol. Cell. Proteomics.11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol.26, 5198.
Nakahara, T., et al. 2007, Cancer Res.67, 8014.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c