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Merck

E0516

Etodolac

Synonym(s):

1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, Etodolic acid, NSC 282126

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About This Item

Empirical Formula (Hill Notation):
C17H21NO3
CAS Number:
41340-25-4
Molecular Weight:
287.35
NACRES:
NA.77
PubChem Substance ID:
24278407
UNSPSC Code:
12352200
MDL number:
MFCD00133313

InChI

1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)

SMILES string

CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12

InChI key

NNYBQONXHNTVIJ-UHFFFAOYSA-N

originator

Wyeth

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Related Categories

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX-1 and COX-2.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000417146
0000417146
0000404552
0000404552
0000188584

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S Lynch et al.
Drugs, 31(4), 288-300 (1986-04-01)
Etodolac is a new non-steroidal agent (NSAID) with anti-inflammatory and analgesic activity. It has been studied in rheumatoid arthritis, osteoarthritis, and pain resulting from minor surgery. In the latter setting, etodolac is at least as effective as aspirin in terms
Yael Goldfarb et al.
Annals of surgery, 253(4), 798-810 (2011-04-09)
Surgical procedures, including primary tumor resection, have been suggested to suppress immune competence and to promote postoperative infections and cancer metastasis. Catecholamines and prostaglandins were recently implicated in these processes, and in directly promoting tumor angiogenesis and invasion. To examine
N Zvaifler
Clinical rheumatology, 8 Suppl 1, 43-53 (1989-03-01)
Etodolac (Lodine, Ramodar, Ultradol), an anti-inflammatory, analgesic agent, is the first of a new class of nonsteroidal anti-inflammatory drugs (NSAIDs), the pyranocarboxylic acids. A review of the literature on numerous clinical studies showed that etodolac (200 to 600 mg/day) is
D R Brocks et al.
Clinical pharmacokinetics, 26(4), 259-274 (1994-04-01)
Etodolac is a chiral nonsteroidal anti-inflammatory drug (NSAID) that is marked as the racemate. Currently, the drug is available in several countries for the treatment of arthritis and the alleviation of pain. Etodolac possesses several unique disposition features mainly due
Soad S Abd el-Hay et al.
Journal of fluorescence, 22(1), 247-252 (2011-08-20)
A simple, selective and sensitive luminescence method has been developed for the assay of etodolac (I), moxepril HCl (II) and fexofenadine HCl (III) in bulk drug and pharmaceutical formulations. The method is based on the luminescence sensitization of europium (Eu(3+))
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