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Merck

420118

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control

The JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control, (L)-HIV-TAT48-57-PP, GRKKRRQRRRPP-NH2

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About This Item

Empirical Formula (Hill Notation):
C65H124N34O13
Molecular Weight:
1589.90
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)

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Product Name

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control, The JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 2 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
A useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-Permeable
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A highly cell-permeable 10-amino acid carrier peptide derived from HIV-TAT48-57 sequence that is modified with two proline residues. Shown to accumulate into a variety of cells. Serves as a useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-Permeable (Cat. No. 420116).
A highly cell-permeable carrier decapeptide derived from HIV-TAT48-57 sequence that is modified with two proline residues. Serves as a useful negative control for studies involving JNK Inhibitor I, (L)-Form, Cell-permeable (Cat. No. 420116).

Other Notes

Bonny, C., et al. 2001. Diabetes50, 77.
Vocero-Akbani, A. M., et al 1999. Nat. Med.5, 29.
Schwarze, S. R., et al. 1999. Science285, 1573.
Nagahara, H., et al. 1998. Nat. Med.4, 1449.
Vives, E., et al. 1997. J. Biol. Chem.272, 16010.
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH₂

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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