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Merck

218717

Casein Kinase II Inhibitor V, Quinalizarin - CAS 81-61-8 - Calbiochem

Synonym(s):

Casein Kinase II Inhibitor V, Quinalizarin - CAS 81-61-8 - Calbiochem, 1,2,5,8- Tetra hydroxy-9,10- anthra quinone, 1,2,5,8-Tetrahydroxy-9,10-anthraquinone

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About This Item

Empirical Formula (Hill Notation):
C14H8O6
CAS Number:
81-61-8
Molecular Weight:
272.21
UNSPSC Code:
12352200
MDL number:
MFCD00001205

Key Documents

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form

solid

InChI

1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H

InChI key

VBHKTXLEJZIDJF-UHFFFAOYSA-N

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

dark red

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Disclaimer

Toxicity: Irritant (B)

General description

This product has been discontinued.



A cell-permeable hydroxylated anthraquinone compound that acts as a potent (IC50 = 110 nM), highly selective (IC50 >1µM against CK1 and 83 other kinases), and ATP-competitive (Ki = 50 nM) CK2 inhibitor with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against DYRK1a, PIM1/3, and HIPK2. Quinalizarin is about 4.3- and 1.9-fold more effective than TBB, respectively, in cellular CK2 activity inhibition and in apoptosis induction in Jurkat cell cultures.

A cell-permeable hydroxylated anthraquinone compound that acts as a potent (IC50 = 110 nM), highly selective (IC50 >1µM against CK1 and 83 other kinases), and ATP-competitive (Ki = 50 nM) CK2 inhibitor with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against DYRK1a, PIM1/3, and HIPK2. Quinalizarin is about 4.3- and 1.9-fold more effective than TBB, respectively, in cellular CK2 activity inhibition and in apoptosis induction in Jurkat cell cultures.

Other Notes

Cozza, G., et al. 2009. Biochem. J.421, 387.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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