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Merck

218832

Caspase-3/7 Inhibitor II

The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-3/7 Inhibitor II, Ac-DNLD-CHO

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About This Item

Empirical Formula (Hill Notation):
C20H31N5O10
CAS Number:
775289-20-8
Molecular Weight:
501.49
MDL number:
MFCD07368597
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Caspase-3/7 Inhibitor II, The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

InChI key

XZGUQURUQBIHMG-XUXIUFHCSA-N

SMILES string

N([C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CC(=O)N

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Analysis Note

Single main spot with additional trace spot by TLC

Biochem/physiol Actions

Cell permeable: no
Primary Target
caspase-3, caspase-7
Product does not compete with ATP.
Reversible: yes
Target IC50: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively

Disclaimer

Toxicity: Standard Handling (A)

General description

A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.

Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).

Other Notes

Ac-Asp-Asn-Leu-Asp-CHO
Yoshimori, A., et al. 2004. BMC Pharmacol.4, 7.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Kamila Říhová et al.
Journal of proteome research, 23(8), 2999-3011 (2024-03-19)
Caspase-9 is traditionally considered the initiator caspase of the intrinsic apoptotic pathway. In the past decade, however, other functions beyond initiation/execution of cell death have been described including cell type-dependent regulation of proliferation, differentiation/maturation, mitochondrial, and endosomal/lysosomal homeostasis. As previous

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