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Merck

344220

Formyl Peptide Receptor-Like 1 Antagonist, WRW4

The Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ controls the biological activity of Formyl Peptide Receptor-Like 1.

Synonym(s):

Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴, H2N-WRWWWW-CONH2, FPRL1 Antagonist, WRW4

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About This Item

Empirical Formula (Hill Notation):
C61H65N15O6
Molecular Weight:
1104.27
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)

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Product Name

Formyl Peptide Receptor-Like 1 Antagonist, WRW4, The Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ controls the biological activity of Formyl Peptide Receptor-Like 1.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)
Product does not compete with ATP.
Reversible: no
Target IC50: 230 nM for FPRL1 Agonist

Disclaimer

Toxicity: Standard Handling (A)

General description

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC50 = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca2+]i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ42 peptide-induced superoxide generation and prevents its internalization in human macrophages.

Other Notes

Bae, Y.S., et al. 2004. J. Immunol.173, 607.
H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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