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Application Notes |
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Cardiovascular Biomarker Application NoteMeasurement of cardiovascular disease biomarkers in human samples using magnetic bead-based MILLIPLEX® multiplex panels
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Measure cardiovascular biomarkers – such as fibrinogen, CRP, and myeloperoxidase – with MILLIPLEX® multiplexed assay kits.
Cardiovascular disease (CVD), particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all deaths annually (WHO). Inflammation pathways play a vital role in the initiation, maintenance and progression of vascular disease, and there is a strong correlation between inflammation biomarkers (such as acute phase proteins) and prognosis in coronary artery disease.
Bring your cardiovascular disease biomarkers to life with MILLIPLEX® Multiplex CVD Assays
For a complete picture of CVD, you need to analyze data for multiple proteins from multiple systems. Trust Merck’s growing MILLIPLEX® portfolio of multiplexed CVD biomarker assays for precise lot-to-lot consistency.
Based on Luminex xMAP® technology, our analytically verified assay kits provide:
- Standards verified to match reference lots
- Serum matrix for generating standard curves that accurately simulate conditions of native analyte conditions in serum or plasma
- In-assay controls
- Detection antibody cocktails to ensure consistent performance regardless of plex size
Some examples of the cardiovascular disease biomarker assay analytes in our portfolio are listed below.
Cardiovascular Disease Biomarkers*:
Biomarkers that may indicate a higher risk for heart disease include:
*only selected analytes listed
Acute Phase Proteins*:
Acute phase proteins are produced in the liver in response to proinflammatory cytokines. The serum concentrations of these proteins change significantly in response to inflammation, and low-grade inflammation has been correlated with cardiovascular disease.
*only selected analytes listed
Apolipoproteins
These proteins bind to and transport lipids through the bloodstream; their levels may correlate with risk of coronary heart disease.
Cardiovascular heart disease may be coincident with metabolic syndrome. Simultaneously measure biomarkers of both disease states by choosing among
MILLIPLEX® metabolism biomarker assay kits.
Numerous studies have demonstrated an association between the inflammation pathway and cardiovascular risk factors. Enrich your CVD studies by adding
MILLIPLEX® inflammation assay panels to your experiments.
Download the Analyte Quarterly brochure for a complete, updated list of assays.
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