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505736 5-BDBD - CAS 768404-03-1 - Calbiochem

505736
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Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₁BrN₂O₂ 768404-03-1

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      Glass bottle 5 mg
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      Description
      OverviewA highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
      Catalogue Number505736
      Brand Family Calbiochem®
      Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
      References
      ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
      Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
      Product Information
      CAS number 768404-03-1
      FormOff-white powder
      Hill FormulaC₁₇H₁₁BrN₂O₂
      Chemical formulaC₁₇H₁₁BrN₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP2X₄
      Primary Target IC<sub>50</sub>500 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      5-BDBD - CAS 768404-03-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Trabanelli, S., et al. 2012. J. Immunol. 189, 1303.
      Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
      DescriptionA highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
      FormOff-white powder
      CAS number 768404-03-1
      Chemical formulaC₁₇H₁₁BrN₂O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (15 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
      Wu, T., et al. 2011. Am. J. Physiol. 301, H69.