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504906 Cuspin-1 - Calbiochem

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504906
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₃H₁₀BrNO
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5 µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24 h; 10 µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number504906
      Brand Family Calbiochem®
      Synonyms(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron protein Upregulator, Cuspin-1
      References
      ReferencesLetso, R.R., et al. 2013. ACS Chem. Biol. 8, 914.
      Product Information
      FormBrown powder
      Hill FormulaC₁₃H₁₀BrNO
      Chemical formulaC₁₃H₁₀BrNO
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRas
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      504906 0

      Documentation

      Cuspin-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Letso, R.R., et al. 2013. ACS Chem. Biol. 8, 914.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-August-2013 JSW
      Synonyms(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron protein Upregulator, Cuspin-1
      DescriptionA cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5 µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24 h; 10 µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.
      FormBrown powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₀BrNO
      Structure formulaStructure formula
      Purity≥94% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLetso, R.R., et al. 2013. ACS Chem. Biol. 8, 914.