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506166 p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem

506166
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₂H₂₆N₄O • 2HCl 259199-65-0
      Description
      Overview

      This product has been discontinued.



      A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml.

      Catalogue Number506166
      Brand Family Calbiochem®
      SynonymsNʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl, p53 Activator V
      References
      ReferencesRao, C.V., et al. 2009. Cancer Res. 69, 8175.
      Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
      Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
      Wischhusen, J., et al. 2003. Oncogene 22, 8233.
      Rippin, T.M., et al. 2002. Oncogene 21, 2119.
      Foster, B.A., et al. 1999. Science 286, 2507.
      Product Information
      CAS number259199-65-0
      FormYellow solid
      Hill FormulaC₂₂H₂₆N₄O • 2HCl
      Chemical formulaC₂₂H₂₆N₄O • 2HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsSolution unstable. Prepare solution just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      506166

      References

      Reference overview
      Rao, C.V., et al. 2009. Cancer Res. 69, 8175.
      Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
      Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
      Wischhusen, J., et al. 2003. Oncogene 22, 8233.
      Rippin, T.M., et al. 2002. Oncogene 21, 2119.
      Foster, B.A., et al. 1999. Science 286, 2507.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2010 RFH
      SynonymsNʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl, p53 Activator V
      DescriptionA cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number259199-65-0
      Chemical formulaC₂₂H₂₆N₄O • 2HCl
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsSolution unstable. Prepare solution just prior to use.
      Toxicity Standard Handling
      ReferencesRao, C.V., et al. 2009. Cancer Res. 69, 8175.
      Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
      Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
      Wischhusen, J., et al. 2003. Oncogene 22, 8233.
      Rippin, T.M., et al. 2002. Oncogene 21, 2119.
      Foster, B.A., et al. 1999. Science 286, 2507.