- 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Bioorganic & medicinal chemistry letters (2009-06-16)
Philip J Skinner, Peter J Webb, Carleton R Sage, T Huong Dang, Cameron C Pride, Ruoping Chen, Susan Y Tamura, Jeremy G Richman, Daniel T Connolly, Graeme Semple
PMID19524438
ABSTRACT
A series of 5-N,N-disubstituted-5-aminopyrazole-3-carboxylic acids were prepared and found to act as highly potent and selective agonists of the G-Protein Coupled Receptor (GPCR) GPR109b, a low affinity receptor for niacin and some aromatic d-amino acids. Little activity was observed at the highly homologous higher affinity niacin receptor, GPR109a.
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Brand
Product Description
Sigma-Aldrich
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%