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203984 2,3-Butanedione 2-Monoxime - CAS 57-71-6 - Calbiochem

An inhibitor of skeletal and cardiac muscle contraction.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BDM

Primary Target: Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
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203984
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
57-71-6C₄H₇NO₂

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203984-500MGCN
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      Description
      OverviewAn inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
      Catalogue Number203984
      Brand Family Calbiochem®
      SynonymsBDM
      References
      ReferencesPhillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
      Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
      Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.
      Product Information
      CAS number57-71-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₄H₇NO₂
      Chemical formulaC₄H₇NO₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
      Primary Target IC<sub>50</sub>18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEK3150000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203984-500MGCN 04055977219951

      Documentation

      2,3-Butanedione 2-Monoxime - CAS 57-71-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      2,3-Butanedione 2-Monoxime - CAS 57-71-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      203984

      References

      Reference overview
      Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
      Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
      Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-October-2017 JSW
      SynonymsBDM
      DescriptionAn inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR).
      FormWhite to off-white solid
      CAS number57-71-6
      RTECSEK3150000
      Chemical formulaC₄H₇NO₂
      Structure formulaStructure formula
      Purity≥98% by GC
      SolubilityMethanol (100 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPhillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154.
      Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305.
      Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24.