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MABF508 Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98

This rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Csf1r, Csfmr, Fms UniProt Number: P09581
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MABF508
25 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, WBRPEMonoclonal Antibody
      Description
      Catalogue NumberMABF508
      DescriptionAnti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98
      Alternate Names
      • Macrophage colony-stimulating factor 1 receptor
      • CSF-1 receptor
      • CSF-1-R
      • CSF-1R
      • M-CSF-R
      • Proto-oncogene c-Fms
      • CD115
      • CSF1-R
      Background InformationThe AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.
      References
      Product Information
      FormatPE
      PresentationPurified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).
      Key Applications
      • Flow Cytometry
      • Western Blotting
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneAFS98
      Concentration0.2 mg/mL
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Csf1r
      • Csfmr
      • Fms
      Purification MethodSize Exclusion Chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.125 µg of this antibody detected CD115 (c-fms) in one million C57Bl/6 peripheral blood cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF508 04053252979330

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies