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MABS31 Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2

Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2 detects level of Calcyclin & has been published & validated for use in WB, ELISA, IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: MLN 4, PRA, CACY, CABP, 2A9, 5B10 UniProt Number: P06703
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MABS31
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ELISA, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS31
      DescriptionAnti-Calcyclin Antibody, clone CPTC-Calcyclin-2
      Alternate Names
      • S100 calcium binding protein A6
      • S100 calcium binding protein A6 (calcyclin)
      • protein S100-A6
      • calcyclin
      • S100 calcium-binding protein A6 (calcyclin)
      • Growth factor-inducible protein 2A9
      • Calcyclin
      • Prolactin receptor-associated protein
      • S100 calcium-binding protein A6
      Background InformationCalcyclin, also known as S100A6, is a calcium binding protein that is highly expressed in fibroblasts and epithelial cells. Inhibition of calcyclin by p53 is part of the mechanism to control cell proliferation. Calcyclin is associated with cancer and metastasis and plays a role in cell cycle regulation.
      References
      Product Information
      FormatPurified
      Control
      • Human lung tissue lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Calcyclin Antibody, clone CPTC-Calcyclin-2 detects level of Calcyclin & has been published & validated for use in WB, ELISA, IH.
      Key Applications
      • Western Blotting
      • ELISA
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.)
      Biological Information
      ImmunogenFull length recombinant protein corresponding to human Calcyclin.

      Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
      CloneCPTC-Calcyclin-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq].
      Gene Symbol
      • MLN 4
      • PRA
      • CACY
      • CABP
      • 2A9
      • 5B10
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: May function as calcium sensor and contribute to cellular calcium signaling Potential. May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.

      SUBUNIT STRUCTURE: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP (By similarity). Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4.

      SUBCELLULAR LOCATION: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side

      INDUCTION: Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.

      PTM: The N-terminus is blocked.

      MISCELLANEOUS: This protein co-purified with the prolactin receptor.

      SEQUENCE SIMILARITIES: Belongs to the S-100 family.

      Contains 2 EF-hand domains.
      Molecular Weight~10 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Calcyclin on 10 µg of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS31 04053252749261

      Documentation

      Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2 Certificates of Analysis

      TitleLot Number
      Anti-Calcyclin, clone CPTC-Calcyclin-2 2472054
      Anti-Calcyclin, clone CPTC-Calcyclin-2 - 2061451 2061451
      Anti-Calcyclin, clone CPTC-Calcyclin-2 - 3440798 3440798
      Anti-Calcyclin, clone CPTC-Calcyclin-2 - NRG1833262 NRG1833262
      Anti-Calcyclin, clone CPTC-Calcyclin-2 -2507146 2507146
      Anti-Calcyclin, clone CPTC-Calcyclin-2 -2585678 2585678
      Anti-Calcyclin, clone CPTC-Calcyclin-2 -2593381 2593381
      Anti-Calcyclin, clone CPTC-Calcyclin-2 -2799091 2799091
      Anti-Calcyclin, clone CPTC-Calcyclin-2 -2802895 2802895