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MABS341 Anti-LRP6 Antibody, clone 1C10

This LRP6 antibody is validated for use in WB & IP for the detection of the LRP6 protein.

Anti-LRP6 Antibody, clone 1C10 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Developmental Signaling Gene Symbol: LRP6 UniProt Number: O75581
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MABS341
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS341
      DescriptionAnti-LRP6 Antibody, clone 1C10
      Alternate Names
      • Low-density lipoprotein receptor-related protein 6
      • LRP-6
      Background InformationLow density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling.
      References
      Product Information
      FormatPurified
      Control
      • HEK293 cell lysate
      PresentationPurified mouse monoclonal IgG containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis LRP6 antibody is validated for use in WB & IP for the detection of the LRP6 protein.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: A representative lot immunoprecipitated LRP6 in certain cell lyates (Khan, Z., et al. (2007). Mol Cell Biol. 27(20):7291-7301.).
      Biological Information
      ImmunogenFlag-tagged recombinant protein corresponding to human LRP6.
      Clone1C10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LRP6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~200 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected LRP6 in 10 µg of HEK293 cell lysate. For enhanced results, it is recommended for end-users to perform higher dilutions of this antibody.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS341 04053252858314

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies