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ABD53 Anti-ZEB1 Antibody

Anti-ZEB1 detects levels of ZEB1 proteins & has been published & validated for use in WB.

Anti-ZEB1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function, Neuroscience Research Sub-Category: Transcription Factors, Developmental Signaling Gene Symbol: ZEB1, AREB6, TCF8 UniProt Number: P37275
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ABD53
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, B, Ch, FgWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABD53
      DescriptionAnti-ZEB1 Antibody
      Alternate Names
      • Zinc finger E-box-binding homeobox 1
      • NIL-2-A zinc finger protein
      • Negative regulator of IL2
      • Transcription factor 8
      • TCF-8
      Background InformationZinc finger E-box-binding homeobox 1 (ZEB1), also known as Transcription factor 8 (TCF8) and Negative regulator of IL2 or NIL-2-A zinc finger protein is a member of the Zinc finger-Homeobox (ZFH)-family of repressors and acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 has also been implicated in regulating the expression of ATP1A1, E-cadherin, BCL6, and RCOR1 genes. ZEB1 regulates neurogenesis and neuronal differentiation, but is also implicated in tumor formation. ZEB1 is expressed in heart and skeletal muscle. Mutations in ZEB1 have been associated with corneal dystrophy.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse embryo e11 tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ZEB1 detects levels of ZEB1 proteins & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human ZEB1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      • Human
      • Bovine
      • Chicken
      • Frog
      Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Bovine, Chicken, and Frog based on 100% sequence homology. Predicted to react with Human based on immunogen design.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZEB1
      • AREB6
      • TCF8
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~200 kDa observed. The calculated molecular weight is 124 kDa, however ZEB1 has been shown at ~180-210 kDa in western blots (Dave, N., et al. (2011). J. Biol. Chem. 286(14):12024-12032).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse embryo e11 tissue lysate.

      Western Blot Analysis: 1.0 µg/mL of this antibody detected ZEB1 in 10 µg of mouse embryo e11 tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABD53 04053252832475

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies