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372770 HBDDE - CAS 154675-18-0 - Calbiochem

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

HBDDE - CAS 154675-18-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether

Primary Target: PKCα
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372770
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154675-18-0C₁₆H₁₈O₈

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372770-1MGCN
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      Description
      OverviewA cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
      Catalogue Number372770
      Brand Family Calbiochem®
      Synonyms2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
      References
      ReferencesMathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
      Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
      Product Information
      CAS number154675-18-0
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₆H₁₈O₈
      Chemical formulaC₁₆H₁₈O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKCα
      Primary Target IC<sub>50</sub>43 µM against PKCα
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      372770-1MGCN 04055977212884

      Documentation

      HBDDE - CAS 154675-18-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      HBDDE - CAS 154675-18-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      372770

      References

      Reference overview
      Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
      Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
      DescriptionProtein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.
      FormOrange solid
      CAS number154675-18-0
      Chemical formulaC₁₆H₁₈O₈
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (5 mg/ml), Ethanol (1 mg/ml), or warm H₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
      Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.