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553008 Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem

The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074

Primary Target: CRAFI kinase
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553008
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
220904-83-6C₁₅H₈Br₂INO₂

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      Description
      OverviewA potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
      Catalogue Number553008
      Brand Family Calbiochem®
      Synonyms5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
      References
      ReferencesLackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.
      Product Information
      CAS number220904-83-6
      ATP CompetitiveY
      FormDark orange solid
      Hill FormulaC₁₅H₈Br₂INO₂
      Chemical formulaC₁₅H₈Br₂INO₂
      HS Code2933 79 90
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCRAFI kinase
      Primary Target IC<sub>50</sub>9 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.



      From Catalog:
      Desc. Field- added "Predicted broad spectrum antitumor agents.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      553008-1MGCN 04055977193404

      Documentation

      Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      553008

      References

      Reference overview
      Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      Synonyms5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive cRaf1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum antitumor agents.
      FormDark orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220904-83-6
      Chemical formulaC₁₅H₈Br₂INO₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.



      From Catalog:
      Desc. Field- added "Predicted broad spectrum antitumor agents.
      Toxicity Standard Handling
      ReferencesLackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223.