N5410
Acide nicotinique
meets USP testing specifications
Synonyme(s) :
Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre
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A propos de cet article
Formule empirique (notation de Hill) :
C6H5NO2
Numéro CAS:
Poids moléculaire :
123.11
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
Service technique
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synthetic (organic)
Quality Segment
agency
USP/NF, meets USP testing specifications
assay
99.0-101.0% dry basis
form
powder
color
white
mp
236-239 °C (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544)
rat ... Chrnb2(54239)
General description
Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.
Application
Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.
Biochem/physiol Actions
Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Classe de stockage
11 - Combustible Solids
flash_point_f
379.4 °F - closed cup
flash_point_c
193 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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