Quality Level
assay
≥95% (HPLC)
form
buffered aqueous solution
concentration
0.1 mg/mL in 0.1 M sodium acetate pH 5.0
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell membrane | interferes
shipped in
dry ice
storage temp.
−20°C
General description
化学结构：肽
Application
片球菌素的分子质量约为2,700至4,000 Da。它们是潜在的食品生物防腐剂，可用于控制食源性病原体和腐败变质。
Biochem/physiol Actions
片球菌素是一种IIa类细菌素，由 乳酸小球菌产生。它们是分子量约2700至4,000 Da的阳离子肽， 对病原菌如 单增李斯特菌、产气荚膜梭菌、粪肠球菌和 金黄色葡萄球菌表现出强烈活性。4 片球菌素的这种抗微生物活性是基于与胞质膜的相互作用，从而导致孔形成和细胞死亡。这些相互作用还会引起膜电位的变化，从而导致质子动力的损失和细胞内离子的流出，最终导致细胞死亡。 它们被证明可以抑制 单增李斯特菌。
Other Notes
50 ug
保存于密闭容器内，置于干燥通风处。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
商品
由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
相关内容
Instructions
A K Bhunia
Applied and environmental microbiology, 60(8), 2692-2696 (1994-08-01)
Monoclonal antibody (MAb) R2-AR against pediocin RS2 was developed. Mice were immunized for 12 weeks with pediocin RS2 conjugated to a polyacrylamide gel. Two hybridoma fusions yielded an MAb that in Western blots (immunoblots) reacted only with pediocins RS2 and
M J Pucci et al.
Applied and environmental microbiology, 54(10), 2349-2353 (1988-10-01)
The bacteriocin produced by Pediococcus acidilactici PAC 1.0, previously designated PA-1 bacteriocin, was found to be inhibitory and bactericidal for Listeria monocytogenes. A dried powder prepared from PAC 1.0 culture supernatant fortified with 10% milk powder was found to contain
Pamela Oliveira de Souza de Azevedo et al.
Scientific reports, 10(1), 12291-12291 (2020-07-25)
Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control.