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530799 AGE Inhibitor, LR-90 - Calbiochem

530799
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₅H₃₄Cl₂N₄O₈

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      Description
      OverviewA cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC50 = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-κB.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530799
      Brand Family Calbiochem®
      SynonymsAdvanced Glycation Endproducts Inhibitor
      References
      ReferencesSatheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
      Nagai, R., et al. 2012. Diabetes. 61, 549.
      Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
      Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.
      Product Information
      FormOff-white powder
      Hill FormulaC₃₅H₃₄Cl₂N₄O₈
      Chemical formulaC₃₅H₃₄Cl₂N₄O₈
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target=IF(SGM_MetricTransfer!C11=,,SGM_MetricTransfer!C11)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AGE Inhibitor, LR-90 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Satheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
      Nagai, R., et al. 2012. Diabetes. 61, 549.
      Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
      Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2014 JSW
      SynonymsAdvanced Glycation Endproducts Inhibitor
      DescriptionA cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC50 = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-kB.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₃₄Cl₂N₄O₈
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSatheesan, S., et al. 2014. Br. J. Pharmacol. 171, 3103.
      Nagai, R., et al. 2012. Diabetes. 61, 549.
      Figarola, J.L., et al. 2008. Diabetologia. 51, 882.
      Figarola, J.L., et al. 2003. Diabetologia. 46, 1140.