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651070 Tubulysin A, Myxobacteria sp. - Calbiochem

651070
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₄₃H₆₅N₅O₁₀S
      Description
      OverviewA cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative (average of estimated GI50 ~ 12 nM in the NCI 60-human cancer cell line panel) as well as antiangiogenic (IC50 = 2.07 and 2.97 nM in inhibiting HUVEC cord junctions and length, respectively) properties. Shown to be efficacious in hollow fiber assays in mice in vivo and exhibit excellent cancer selectivity (100% and 0% apotosis induction at 10 nM in HL-60 and HUVEC cells, respectively) in vitro.
      Catalogue Number651070
      Brand Family Calbiochem®
      SynonymstubA
      References
      ReferencesKaur, G., et al. 2006. Biochem. J. 396, 235.
      Steinmetz, H., et al. 2004. Angew. Chem. 43, 4888.
      Sasse, F., et al. 2000. J. Antibiot. 53, 879.
      Product Information
      ATP CompetitiveN
      DeclarationLicensed from Helmholtz Centre for Infection Research (former GBF) in Braunschweig, Germany.
      FormWhite solid
      Hill FormulaC₄₃H₆₅N₅O₁₀S
      Chemical formulaC₄₃H₆₅N₅O₁₀S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAnti-microtubule agent
      Primary Target IC<sub>50</sub>2.07 and 2.97 nM in inhibiting HUVEC cord junctions and length, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tubulysin A, Myxobacteria sp. - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Tubulysin A, Myxobacteria sp. - Calbiochem Certificates of Analysis

      TitleLot Number
      651070

      References

      Reference overview
      Kaur, G., et al. 2006. Biochem. J. 396, 235.
      Steinmetz, H., et al. 2004. Angew. Chem. 43, 4888.
      Sasse, F., et al. 2000. J. Antibiot. 53, 879.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2008 JSW
      SynonymstubA
      DescriptionA cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative (average of estimated GI50 ~ 12 nM in the NCI 60-human cancer cell line panel) as well as antiangiogenic (IC50 = 2.07 and 2.97 nM in inhibiting HUVEC cord junctions and length, respectively) properties. Shown to be efficacious in hollow fiber assays in mice in vivo and exhibit excellent cancer selectivity (100% and 0% apotosis induction at 10 nM in HL-60 and HUVEC cells, respectively) in vitro.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₃H₆₅N₅O₁₀S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      ReferencesKaur, G., et al. 2006. Biochem. J. 396, 235.
      Steinmetz, H., et al. 2004. Angew. Chem. 43, 4888.
      Sasse, F., et al. 2000. J. Antibiot. 53, 879.