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219334

β-Catenin/Tcf Inhibitor V

BC21

Synonym(s):

β-Catenin/Tcf Inhibitor V, ICAT, Inhibitor of beta-catenin and Tcf

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About This Item

Linear Formula:
C32H36Cl2Cu2N2O2
CAS Number:
691005-38-6
MDL number:
MFCD00190613
NACRES:
NA.28
UNSPSC Code:
12352200
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Quality Segment

100

form

(Dark brown solid)

solubility

soluble (DMSO (0.5 mg/ml). Poorly soluble in water.)

storage temp.

2-8°C

General description

A cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).

pictograms

Corrosion
GHS05

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Certificates of Analysis (COA)

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