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Bioactive small molecules

Schematic demonstrating a bioactive small molecule (stick diagram) binding to protein complex (pink and cyan molecules), effecting biological function.

Our catalog of more than 4,000 bioactive small molecules unlocks new possibilities for exploring biology and enabling early drug discovery. Designed to help researchers investigate protein targets, signaling pathways and disease mechanisms, our diverse portfolio makes it easier to find the right compounds for your next experiment. Our portfolio includes small molecule inhibitors, such as selective kinase and cell signaling inhibitors, agonists, and toxins. These compounds are useful tools for biochemical, biophysical, and cell-based assays.

Furthermore, our partnership with the Structural Genomics Consortium provides highly characterized, novel chemical probes that guide early small molecule drug discovery from hit identification to target validation. Explore our collection of these highly adaptable research tools to discover the compounds that can accelerate your drug discovery.

Need help finding a bioactive small molecule?

Use our bioactive small molecule explorer to find your fit-for-purpose probe. 

A laboratory technician in a white lab coat and green gloves is using a pipette to transfer bioactive small molecule inhibitors into a black microplate. Various laboratory supplies, including bottles of reagents and a pink rack for test tubes, are visible on the table, alongside a document with printed instructions. In the background, laboratory equipment is partially visible.

Bioactive small molecule inhibitors

Discover our portfolio of bioactive small molecule inhibitors for dissecting biological systems, validating drug targets, and advancing cancer therapy.

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Bioactive small molecule agonists

Discover our collection of bioactive small molecule agonists for signaling pathways, drug discovery, and cancer and cardiovascular disease research.

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Scientist looking at a vial in her hand. There is a collection of vials of bioactive small molecules in front of her. In the background another scientist walks towards her.

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A scientist sits at the lab bench wearing lab goggles, a lab coat, and gloves. She is pipetting bioactive small molecules. Behind her another scientist wearing a lab coat and goggles is using a multichannel pipettor. There are instruments and pipette tips on the right of the image.
Bioactive small molecule toxins

Explore our collection of bioactive small molecule toxins for toxicology, signal transduction, neuroscience, and cardiovascular biology research.

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Female scientist in a white laboratory coat, wearing blue gloves and face mask at a microscope holding an Eppendorf tube working on target validation using SGC chemical probes. Two other scientists are in the background also working at the bench.
Structural Genomics Consortium

Structural Genomics Consortium (SGC) chemical probes for target validation and numerous additional research applications and workflow needs.

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