I3657
Insulin-Like Growth Factor Binding Protein-2 from mouse
≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Synonym(s):
IGFBP-2
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About This Item
biological source
mouse
Quality Segment
recombinant
expressed in NSO cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
0.125-0.5 mg per mL ED50
mol wt
~35 kDa by SDS-PAGE (reducing), calculated mol wt 29.4 kDa
packaging
pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Igfbp2(16008)
General description
IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.
Biochem/physiol Actions
During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.
Physical form
Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.
Analysis Note
The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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