175580 Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem

175580
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₂H₉N₃O186611-44-9

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175580-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
      Catalogue Number175580
      Brand Family Calbiochem®
      Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
      References
      ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
      Product Information
      CAS number186611-44-9
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₂H₉N₃O
      Chemical formulaC₁₂H₉N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargethEGF-R tyrosine kinase activity
      Primary Target IC<sub>50</sub>54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      175580

      References

      Reference overview
      Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
      DescriptionA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number186611-44-9
      Chemical formulaC₁₂H₉N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.