203408 BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem

203408
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl55658-47-4

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203408-250MG
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      Plastic ampoule 250 mg
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      Description
      OverviewA unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ Antibiotic cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
      Catalogue Number203408
      Brand Family Calbiochem®
      References
      ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
      Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
      Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
      Takita, T., et al. 1972. J. Antibiot. 25, 755.
      Product Information
      CAS number55658-47-4
      FormBlue lyophilized solid
      Hill FormulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
      Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥85% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEC5990700
      Safety Information
      R PhraseR: 20/21/22-36/37/38-40-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      203408

      References

      Reference overview
      Sergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
      Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
      Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
      Takita, T., et al. 1972. J. Antibiot. 25, 755.

      Brochure

      Title
      Antibiotics Profiler
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-September-2007 RFH
      DescriptionA unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
      FormBlue lyophilized solid
      CAS number55658-47-4
      RTECSEC5990700
      Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
      Structure formulaStructure formula
      Purity≥85% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
      Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
      Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
      Takita, T., et al. 1972. J. Antibiot. 25, 755.