211200 CAPE - CAS 104594-70-9 - Calbiochem

211200
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₇H₁₆O₄104594-70-9

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211200-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.
      Catalogue Number211200
      Brand Family Calbiochem®
      SynonymsCaffeic Acid Phenethyl Ester, Synthetic
      References
      ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
      Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
      Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
      Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
      Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
      Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
      Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
      Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
      Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.
      Product Information
      CAS number104594-70-9
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₁₇H₁₆O₄
      Chemical formulaC₁₇H₁₆O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHIV-integrase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CAPE - CAS 104594-70-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CAPE - CAS 104594-70-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      211200

      References

      Reference overview
      Nicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
      Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
      Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
      Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
      Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
      Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
      Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
      Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
      Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCaffeic Acid Phenethyl Ester, Synthetic
      DescriptionA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK) and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number104594-70-9
      Chemical formulaC₁₇H₁₆O₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml) and Ethanol (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
      Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
      Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
      Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
      Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
      Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
      Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
      Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
      Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.